The 2nd International Conference on Global Plant Humanities at Tribhuvan University, Kathmandu, Nepal, 2–3 May 2025, will further the dialogue between the arts, humanities, social sciences, and natural sciences towards novel perspectives on the botanical world and human-flora relations. Highlighting cross-cultural understandings of plant life, the conference will focus on developments in Plant Humanities scholarship across the globe but with emphasis on the biocultural diversity of South Asian countries (Bangladesh, Bhutan, India, the Maldives, Nepal, Pakistan, and Sri Lanka).